PRIME aims to go beyond the state-of-the-art generating a robust platform to create a new generation of active, tubeless and contactless microfluidic chips effectively changing the currently established paradigm. PRIME will develop a radically new platform that: i) integrates all the required responsive materials and elements in the chip, effectively providing it with all the fluidic and sensing functions, ii) uses compatible materials and manufacturing technologies making future industrial production viable and cost-effective, iii) allows to implement with extensive freedom of design a plethora of new smart-integrated and easy-to-operate microfluidic chips.